Treatments for Stage IV Colon Cancer and Overall Survival.

  title={Treatments for Stage IV Colon Cancer and Overall Survival.},
  author={Zhaomin Xu and Adan Z. Becerra and Fergal J. Fleming and Christopher T. Aquina and James G. Dolan and John Monson and Larissa Temple and Todd A. Jusko},
  journal={The Journal of surgical research},

The Impact of Primary Tumor Resection on Survival in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases

It is shown that asymptomatic CRC patients with unresectable metastases could gain a survival benefit from upfront PTR by analysis with the inverse probability of treatment weighting (IPTW) method, but randomized controlled trials are mandatory.

Primary Tumor Resection in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases: Can It Improve Survival?

It is suggested that asymptomatic CRC patients with unresectable metastases could gain a survival benefit from upfront PTR using the ‘inverse probability of treatment weighting’ method, which is a recently emerging statistical tool to minimize selection bias by adjusting the baseline confounders.

Care Management and Survival of Patients Diagnosed with Synchronous Metastatic Colorectal Cancer: A High-Resolution Population-Based Study in Two French Areas

The results indicate that a combined treatment, chemotherapy and primary tumor resection, is the cornerstone of oncological management, with survival being negatively impacted by other treatment strategies.

Asymptomatic Primary Tumor Resection in Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

The results from studies demonstrate that the resection of primary tumor is a prognostic factor for survival in mCRC patients, but 2 RCTs showed the resections was not related with a significant survival benefit in subgroup, therefore, a larger RCT in the era of modern chemotherapy and liver resection techniques would be helpful.

Early versus late closure of temporary ileostomy after rectal cancer surgery: a meta-analysis

With fewer overall and wound-related complications, LC tended to be more suitable than EC for rectal cancer patients with a temporary ileostomy; however, the complications before closure should also be considered.

Dysregulation of MiR-144-5p/RNF187 Axis Contributes To the Progression of Colorectal Cancer

The deregulation of miR-144-5p/ RNF187 axis in CRC, as well as its role in regulation of the tumor progression, is demonstrated, thus providing a novel therapeutic strategy for CRC treatment.

Targeting the lncRNA FGD5-AS1/miR-497-5p/PD-L1 Axis Inhibits Malignant Phenotypes in Colon Cancer (CC)

It is found that lncRNA FGD5-AS1 sponged miR-497-5p to upregulate PD-L1, resulting in CC progression, and provided novel agents for CC diagnosis and prognosis.

Computational study, synthesis and evaluation of active peptides derived from Parasporin-2 and spike protein from Alphacoronavirus against colorectal cancer cells

The results suggest that native peptide fragments from Ps2Aa1 may be optimized as a novel potential cancer-therapeutic agents.

The perils of toxic masculinity: four case studies

The term ‘toxic masculinity’ is increasingly used to describe cultural masculine norms that are harmful to the men themselves and society in general. Here the authors illustrate, through case



Time trend analysis of primary tumor resection for stage IV colorectal cancer: less surgery, improved survival.

The majority of patients with stage IV CRC had undergone primary tumor resection but, beginning in 2001, a trend toward fewer primary tumors resection was seen, and current treatment practices lag behind evidence-based treatment guidelines.

Primary Tumor Resection Is Associated with Improved Survival in Stage IV Colorectal Cancer: An Instrumental Variable Analysis

Instrumental variable analyses revealed that PTR was associated with better overall, cancer-specific, and other-cause survival of patients with unresectable stage IV CRC, and the median overall survival increased for both PTR and non-PTR patients.

Emergent Colectomy Is Independently Associated with Decreased Long-Term Overall Survival in Colon Cancer Patients

Emergent resection for colon cancer is independently associated with poor short-term outcomes and decreased 5-year OS compared to elective resection, underlie the importance of adherence to colon cancer screening guidelines to limit the need for emergent resections.

Surgical Resection of the Primary Tumor in Stage IV Colorectal Cancer Without Metastasectomy Is Associated With Improved Overall Survival Compared With Chemotherapy/Radiation Therapy Alone

Surgical resection of the primary tumor without metastasectomy in patients with metastatic colorectal cancer is associated with improved survival as compared with chemotherapy/radiation therapy alone.

Prognostic Value of Resection of Primary Tumor in Patients with Stage IV Colorectal Cancer: Retrospective Analysis of Two Randomized Studies and a Review of the Literature

It is indicated that resection of the primary tumor is a prognostic factor for survival in stage IV CRC patients and the potential bias of these results warrants prospective studies on the value of resections of primary tumor in this setting.

Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: a pooled analysis of two randomized trials.

  • E. MitryA. Fields P. Rougier
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
A pooled analysis shows a marginal statistical significance in favor of adjuvant chemotherapy with an FU bolus-based regimen after complete resection of colorectal cancer metastases, independently associated with both progression-free survival and overall survival in multivariable analysis.