Treatments for Stage IV Colon Cancer and Overall Survival.

@article{Xu2019TreatmentsFS,
  title={Treatments for Stage IV Colon Cancer and Overall Survival.},
  author={Zhaomin Xu and Adan Z. Becerra and Fergal J. Fleming and Christopher T. Aquina and James G. Dolan and John Monson and Larissa Temple and Todd A. Jusko},
  journal={The Journal of surgical research},
  year={2019},
  volume={242},
  pages={
          47-54
        }
}

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The majority of patients with stage IV CRC had undergone primary tumor resection but, beginning in 2001, a trend toward fewer primary tumors resection was seen, and current treatment practices lag behind evidence-based treatment guidelines.

Primary Tumor Resection Is Associated with Improved Survival in Stage IV Colorectal Cancer: An Instrumental Variable Analysis

Instrumental variable analyses revealed that PTR was associated with better overall, cancer-specific, and other-cause survival of patients with unresectable stage IV CRC, and the median overall survival increased for both PTR and non-PTR patients.

Emergent Colectomy Is Independently Associated with Decreased Long-Term Overall Survival in Colon Cancer Patients

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Surgical Resection of the Primary Tumor in Stage IV Colorectal Cancer Without Metastasectomy Is Associated With Improved Overall Survival Compared With Chemotherapy/Radiation Therapy Alone

Surgical resection of the primary tumor without metastasectomy in patients with metastatic colorectal cancer is associated with improved survival as compared with chemotherapy/radiation therapy alone.

Prognostic Value of Resection of Primary Tumor in Patients with Stage IV Colorectal Cancer: Retrospective Analysis of Two Randomized Studies and a Review of the Literature

It is indicated that resection of the primary tumor is a prognostic factor for survival in stage IV CRC patients and the potential bias of these results warrants prospective studies on the value of resections of primary tumor in this setting.

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