Treatments for Methamphetamine Abuse

  title={Treatments for Methamphetamine Abuse},
  author={Todd Brackins and Nancy Brahm and Julie C. Kissack},
  journal={Journal of Pharmacy Practice},
  pages={541 - 550}
Methamphetamine (METH) use and dependence is a serious public health concern with implications across multiple areas from societal impact to burden on psychiatric and medical resources. An estimated 8% of admissions to substance abuse treatment programs are related to stimulants with METH/amphetamine abuse. To date, effective pharmacotherapy options to enhance abstinence have not been identified. The objective of this article is to critically review the literature of METH treatment options… 

Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.

Efficacy of psychostimulant drugs for amphetamine abuse or dependence.

Results of this review do not support the use of psychostimulant medications at the tested doses as a replacement therapy for amphetamine abuse or dependence.

Methamphetamine Dependence : A Double-blind Controlled , Crossover Study

Current standard treatment of METH dependence is the Matrix Model, which combines cognitive, behavioral, and psychological approaches of Meth dependency, which may improves compliance and reduces the relapse.

eview ethamphetamine : An update on epidemiology , pharmacology , linical phenomenology , and treatment literature

This review provides a broad-based update of the available literature covering methamphetamine research over the past two decades and concludes with recommendations for future research into methamphetamine addiction.

Aripiprazole, alcohol and substance abuse: a review.

Given the low number of studies, the frequent absence of placebo or active comparators, and the low statistical power of the studies, a clear conclusion about the use of aripiprazole in alcohol/substance dependence cannot be drawn and the need for further studies is suggested.

Methamphetamine (YABA) Abuse: A Case Study in Young Male

The patient is a student of private university of 24 year old male with a history of YABA addiction for 4 years, who collects drugs from the local spots or particular person and cannot take methamphetamine without having it, peevish temperament occurs.

Improving Rehabilitative Care of Methamphetamine Users in Germany: The Expert’s Perspective

Findings indicate that inadequate rehabilitation is being provided for methamphetamine users in Germany, indicating a need to adapt treatment for this group.

Oxytocin-enhanced motivational interviewing group therapy for methamphetamine use disorder in men who have sex with men: study protocol for a randomized controlled trial

Findings from this novel protocol will attempt to bridge existing animal data with the need for innovative clinical treatments for MUD, inform the growing field of pharmacologically-enhanced psychotherapy, and help to elucidate mechanisms behind oxytocin’s potential anti-addiction effects.

Comparison of Characteristics of Methamphetamine Versus Opiate Users in Tehran, Iran

The findings of the study showed that, compared with the opiate users, methamphetamine users are younger, more likely to be single, and less likely to have received treatment.



An Exploratory Study: The Use of Paroxetine for Methamphetamine Craving

The preliminary data suggest that serotonergic agents may play a role in the effective treatment of methamphetamine abuse and dependence within the context of other effective behavioral interventions.

Evaluation of subjective effects of aripiprazole and methamphetamine in methamphetamine-dependent volunteers.

It is suggested that 15 mg aripiprazole is unlikely to be efficacious for the treatment of Meth dependence, although further research with lower doses of aripIPrazole, possibly using study designs aimed at evaluating efficacy for relapse prevention, are needed before ruling out arip iprazole as a treatment for Meth dependence.

Bupropion for the Treatment of Methamphetamine Dependence

The data suggest that bupropion, in combination with behavioral group therapy, was effective for increasing the number of weeks of abstinence in participants with low-to-moderate methamphetamine dependence, mainly male patients, regardless of their comorbid condition.

Methamphetamine Quantitative Urine Concentrations during a Controlled Trial of Fluoxetine Treatment: Preliminary Analysis

Quantitative determination of drug and metabolite levels in biofluids is increasingly being used in the measurement of outcome, particularly in clinical trials where it is necessary to measure urine outcomes more exactly, in order to substantiate self-reports of decreasing drug use.

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of methamphetamine dependence.

The preliminary results do not support the utility of ondansetron, at the doses tested, as a treatment for methamphetamine dependence and should be viewed in light of the possibility that a less intensive cognitive behavioural therapy regimen might have yielded more positive results in this initial phase II trial.

Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence.

The increased retention in the dexamphetamine group, together with the general decreases in methamphetamine use, degree of dependence and withdrawal symptom severity, provide preliminary evidence that this may be an efficacious treatment option for methamphetamine dependence.

Aripiprazole as a potential pharmacotherapy for stimulant dependence: human laboratory studies with d-amphetamine.

  • W. Stoops
  • Psychology, Biology
    Experimental and clinical psychopharmacology
  • 2006
Two human laboratory studies are reviewed that tested the ability of aripiprazole, a novel antipsychotic with partial agonist activity at D2 dopamine receptors, to alter the behavioral effects of stimulants using d-amphetamine as a model agent to indicate that aripIPrazole may have clinical utility in treating stimulant dependence.

Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence.

A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence.

Methylphenidate is an effective treatment for reducing intravenous drug use in patients with severe amphetamine dependence and should be considered as a treatment for nausea, vomiting, and diarrhea.