Treatments for Methamphetamine Abuse

@article{Brackins2011TreatmentsFM,
  title={Treatments for Methamphetamine Abuse},
  author={Todd Brackins and Nancy Brahm and J. Kissack},
  journal={Journal of Pharmacy Practice},
  year={2011},
  volume={24},
  pages={541 - 550}
}
Methamphetamine (METH) use and dependence is a serious public health concern with implications across multiple areas from societal impact to burden on psychiatric and medical resources. An estimated 8% of admissions to substance abuse treatment programs are related to stimulants with METH/amphetamine abuse. To date, effective pharmacotherapy options to enhance abstinence have not been identified. The objective of this article is to critically review the literature of METH treatment options… Expand
Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.
TLDR
This review provides a broad-based update of the available literature covering methamphetamine research over the past two decades and concludes with recommendations for future research. Expand
Efficacy of psychostimulant drugs for amphetamine abuse or dependence.
TLDR
Results of this review do not support the use of psychostimulant medications at the tested doses as a replacement therapy for amphetamine abuse or dependence. Expand
Methamphetamine Dependence : A Double-blind Controlled , Crossover Study
M ethamphetamine (METH) is a psycho-stimulant drug, and its dependence causes many public health problems, and criminal justice cases. According to estimation of the United Nations, globally thereExpand
Evidence-Based Guidelines for the Pharmacological Management of Acute Methamphetamine-Related Disorders and Toxicity.
TLDR
The development of interdisciplinary and evidence- and consensus-based (S3) German Guidelines was based on a systematic literature and guideline search on therapeutic interventions in methamphetamine-related disorders and recommended second-generation antipsychotics should be favored, given their more favorable side-effect profile. Expand
eview ethamphetamine : An update on epidemiology , pharmacology , linical phenomenology , and treatment literature
Background: Despite initial reports of a decline in use in the early 2000s, methamphetamine remains a significant public health concern with known neurotoxic and neurocognitive effects to the user.Expand
Aripiprazole, alcohol and substance abuse: a review.
TLDR
Given the low number of studies, the frequent absence of placebo or active comparators, and the low statistical power of the studies, a clear conclusion about the use of aripiprazole in alcohol/substance dependence cannot be drawn and the need for further studies is suggested. Expand
Methamphetamine (YABA) Abuse: A Case Study in Young Male
TLDR
The patient is a student of private university of 24 year old male with a history of YABA addiction for 4 years, who collects drugs from the local spots or particular person and cannot take methamphetamine without having it, peevish temperament occurs. Expand
Identification of Treatment Targets in a Genetic Mouse Model of Voluntary Methamphetamine Drinking.
TLDR
A genetic animal model comprised of lines of mice selectively bred for high and low voluntary methamphetamine intake was developed to identify risk and protective alleles for methamphetamine consumption, and identify therapeutic targets. Expand
Improving Rehabilitative Care of Methamphetamine Users in Germany: The Expert’s Perspective
TLDR
Findings indicate that inadequate rehabilitation is being provided for methamphetamine users in Germany, indicating a need to adapt treatment for this group. Expand
Best Practices: Managing Methamphetamine Withdrawal
TLDR
To understand and address the unique challenges of methamphetamine withdrawal from the perspective of client and staff experiences, thirty-four semi-structured interviews were conducted with Withdrawal Management staff and clients in London, Ontario to identify common themes. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
An Exploratory Study: The Use of Paroxetine for Methamphetamine Craving
TLDR
The preliminary data suggest that serotonergic agents may play a role in the effective treatment of methamphetamine abuse and dependence within the context of other effective behavioral interventions. Expand
Evaluation of subjective effects of aripiprazole and methamphetamine in methamphetamine-dependent volunteers.
TLDR
It is suggested that 15 mg aripiprazole is unlikely to be efficacious for the treatment of Meth dependence, although further research with lower doses of aripIPrazole, possibly using study designs aimed at evaluating efficacy for relapse prevention, are needed before ruling out arip iprazole as a treatment for Meth dependence. Expand
Bupropion for the Treatment of Methamphetamine Dependence
TLDR
The data suggest that bupropion, in combination with behavioral group therapy, was effective for increasing the number of weeks of abstinence in participants with low-to-moderate methamphetamine dependence, mainly male patients, regardless of their comorbid condition. Expand
Methamphetamine Quantitative Urine Concentrations during a Controlled Trial of Fluoxetine Treatment: Preliminary Analysis
TLDR
Quantitative determination of drug and metabolite levels in biofluids is increasingly being used in the measurement of outcome, particularly in clinical trials where it is necessary to measure urine outcomes more exactly, in order to substantiate self-reports of decreasing drug use. Expand
A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of methamphetamine dependence.
TLDR
The preliminary results do not support the utility of ondansetron, at the doses tested, as a treatment for methamphetamine dependence and should be viewed in light of the possibility that a less intensive cognitive behavioural therapy regimen might have yielded more positive results in this initial phase II trial. Expand
Randomized, placebo-controlled trial of sertraline and contingency management for the treatment of methamphetamine dependence.
TLDR
These data suggest sertraline is contraindicated for methamphetamine dependence, and provide support for the use of contingency management for treatment of methamphetamine dependence. Expand
Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence.
TLDR
The increased retention in the dexamphetamine group, together with the general decreases in methamphetamine use, degree of dependence and withdrawal symptom severity, provide preliminary evidence that this may be an efficacious treatment option for methamphetamine dependence. Expand
Aripiprazole as a potential pharmacotherapy for stimulant dependence: human laboratory studies with d-amphetamine.
  • W. Stoops
  • Psychology, Medicine
  • Experimental and clinical psychopharmacology
  • 2006
TLDR
Two human laboratory studies are reviewed that tested the ability of aripiprazole, a novel antipsychotic with partial agonist activity at D2 dopamine receptors, to alter the behavioral effects of stimulants using d-amphetamine as a model agent to indicate that aripIPrazole may have clinical utility in treating stimulant dependence. Expand
Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence.
TLDR
While gabapentin does not appear to be effective in treating methamphetamine dependence, baclofen may have a small treatment effect relative to placebo. Expand
A comparison of aripiprazole, methylphenidate, and placebo for amphetamine dependence.
TLDR
Methylphenidate is an effective treatment for reducing intravenous drug use in patients with severe amphetamine dependence and should be considered as a treatment for nausea, vomiting, and diarrhea. Expand
...
1
2
3
...