Treatments (12 and 48 h) with systemic and brain-selective hypothermia techniques after permanent focal cerebral ischemia in rat.

@article{Clark2009TreatmentsA,
  title={Treatments (12 and 48 h) with systemic and brain-selective hypothermia techniques after permanent focal cerebral ischemia in rat.},
  author={Darren L. Clark and Mark Penner and Shannon Wowk and Ian M Orellana-Jordan and Frederick Colbourne},
  journal={Experimental neurology},
  year={2009},
  volume={220 2},
  pages={391-9}
}
Mild hypothermia lessens brain injury when initiated after the onset of global or focal ischemia. The present study sought to determine whether cooling to approximately 33 degrees C provides enduring benefit when initiated 1 h after permanent middle cerebral artery occlusion (pMCAO, via electrocautery) in adult rats and whether protection depends upon treatment duration and cooling technique. In the first experiment, systemic cooling was induced in non-anesthetized rats through a whole-body… CONTINUE READING

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