Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice

  title={Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice},
  author={S. Weber and V. Volynets and G. Kanuri and I. Bergheim and S. Bischoff},
  journal={International Journal of Obesity},
  • S. Weber, V. Volynets, +2 authors S. Bischoff
  • Published 2009
  • Chemistry, Medicine
  • International Journal of Obesity
  • Objective:Sugar consumption has increased markedly over the last few decades and parallels the dramatic increase in overweight and obesity. Data obtained from animal studies suggest that the intestinal serotonergic system and herein particularly the serotonin receptor 3 (5-HT3R) may be involved in sugar detection and short-term control of food intake. Using a mouse model, we tested the hypothesis that blocking 5-HT3R prevents the development of sugar-induced obesity.Design:For 8 weeks, C57BL/J6… CONTINUE READING
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