Treatment with subthreshold doses of caffeine plus trihexyphenidyl fully restores locomotion and exploratory activity in reserpinized rats

@article{MooPuc2004TreatmentWS,
  title={Treatment with subthreshold doses of caffeine plus trihexyphenidyl fully restores locomotion and exploratory activity in reserpinized rats},
  author={Rosa Esther Moo-Puc and Jairo Villanueva-Toledo and Gloria Arankowsky-Sandoval and Fernando Jos{\'e} {\'A}lvarez-Cervera and Jos{\'e}L. G{\'o}ngora-Alfaro},
  journal={Neuroscience Letters},
  year={2004},
  volume={367},
  pages={327-331}
}
Trihexyphenidyl (THP) is a drug commonly used to reduce parkinsonian symptoms. An important side effect of this agent is memory impairment. Since caffeine enhances the potency of THP to inhibit haloperidol-induced catalepsy, caffeine may be used as an adjuvant of lower doses of THP, in order to improve its antiparkinsonian effects without causing memory disruption. To further assess the synergism between caffeine and THP, both drugs were tested in reserpinized rats, another preclinical model of… Expand
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