Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension.

@article{Hollatz2012TreatmentWS,
  title={Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension.},
  author={Trina J Hollatz and Alexandru I. Musat and Susanne Westphal and Catherine F. Decker and Anthony M D'alessandro and Jon G. Keevil and Li Zhanhai and James R Runo},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2012},
  volume={18 6},
  pages={686-95}
}
Portopulmonary hypertension (PoPH) refers to pulmonary arterial hypertension associated with portal hypertension with or without evidence of an underlying liver disease. Despite the potential for curing PoPH with liver transplantation, the presence of moderate or severe PoPH is associated with increased morbidity and mortality and is, therefore, a contraindication to transplantation. Previous studies have predominantly used intravenous epoprostenol for treatment in order to qualify patients for… CONTINUE READING