Treatment with raloxifene and 17beta-estradiol differentially modulates nitric oxide and prostanoids in venous endothelium and platelets of ovariectomized pigs.

@article{Lewis2006TreatmentWR,
  title={Treatment with raloxifene and 17beta-estradiol differentially modulates nitric oxide and prostanoids in venous endothelium and platelets of ovariectomized pigs.},
  author={Debra A. Lewis and Murat Avsar and Peter Labreche and Margarita P Bracamonte and Muthuvel Jayachandran and Virginia M Miller},
  journal={Journal of cardiovascular pharmacology},
  year={2006},
  volume={48 5},
  pages={231-8}
}
Oral treatment with raloxifene, a synthetic estrogen receptor modulator (SERM), or 17beta-estradiol (E2) increases risk for venous thrombosis in women. Acute application of either substance releases endothelium-derived factors from isolated femoral veins but it is not known how their chronic use affects venous functions or the interaction of platelets with veins. This study tested the hypothesis that treatment of ovariectomized animals with oral raloxifene or E2 would increase release of… CONTINUE READING