Treatment with phytoestrogen α-zearalanol might protect neurons of hippocampus in ovariectomized rats

@article{Dong2006TreatmentWP,
  title={Treatment with phytoestrogen α-zearalanol might protect neurons of hippocampus in ovariectomized rats},
  author={Yi-long Dong and Yun Yue and Feng-hua Liu and Sen-yang Lang and Xiao-chun Zhang and Shun-ling Dai and Qin-sheng Ge and Professor Ping-ping Zuo},
  journal={Endocrine},
  year={2006},
  volume={30},
  pages={249-254}
}
Although neuroprotective effects of estrogen on postmenopausal women have been recognized, an associated increased incidence of uterine and breast tumors has jeopardized the clinical use of estrogen. This study was designed to evaluate the neuroprotective effects of a novel phytoestrogen α-zearalanol (α-ZAL), on ovariectomized (OVX) rats. Adult Wistar rats were ovariectomized or sham-operated and treatment with equivalent doses of 17β-estradiol or α-ZAL for 5 wk. Uteruses have been weighted and… CONTINUE READING