Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

@article{Noh2011TreatmentWO,
  title={Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism},
  author={Jeong Sook Noh and Chan Hum Park and Takako Yokozawa},
  journal={British Journal of Nutrition},
  year={2011},
  volume={106},
  pages={1013 - 1022}
}
We have identified the effects of oligonol, a low-molecular polyphenol derived from lychee fruit, on oxidative stress and lipid metabolism in a type 2 diabetic model. Oligonol was orally administered at 10 or 20 mg per kg body weight per d for 8 weeks to db/db mice, and its effects were compared with those of the vehicle in db/db and m/m mice. Serum and hepatic biochemical factors, and protein and mRNA expression related to lipid metabolism were measured. In the oligonol-administered group… 
View on Cambridge Press
cambridge.org
61 Citations
Highly Influential Citations
1
Background Citations
23
Methods Citations
2

61 Citations

Effect of Oligonol, a Low Molecular Weight Polyphenol Derived from Lychee on Oxidative Stress-Related Hepatic Damage in Streptozotocin-Induced Diabetic Rats

Results provide important evidence that oligonol exhibits an inhibitory effect on oxidative stress and apoptosis-related protein expression as well as a hepato-protective effect against the development of diabetic complications in STZ-induced type 1 diabetic rats.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats.

It is suggested that oligonol protects the pancreas from Bax and PDX-1 via oxidative stress for the prevention or delaying of diabetes mellitus.

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates diabetes-induced renal damage through the advanced glycation end product-related pathway in db/db mice.

Results provide important evidence that oligonol exhibits a pleiotropic effect on AGE formation and apoptosis-related variables, representing renoprotective effects against the development of diabetic complications in db/db mice with type 2 diabetes.

Oligonol, a low‐molecular‐weight polyphenol derived from lychee peel, attenuates diabetes‐induced pancreatic damage by inhibiting inflammatory responses via oxidative stress‐dependent mitogen‐activated protein kinase/nuclear factor‐kappa B signaling

It is concluded that a plausible mechanism of oligonol's antidiabetic action may be its antioxidative stress‐related anti‐inflammatory action.

Protective Effect of Oligonol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats via the JNK/NF-κB and PI3K/Akt/Nrf2 Signaling Pathways

Oligonol showed antioxidative, hepatoprotective, and anti-fibrotic effects via JNK/NF-κB and PI3K/Akt/Nrf2 signaling pathways in DMN-intoxicated rats, suggesting that antioxidant oligonol is a potentially useful agent for the protection against chronic liver injury.

Oligonol Attenuates Diabetes-Induced Pancreatic Damage by Inhibiting Inflammatory Responses via Oxidative Stress-Dependent MAPK/NF-kB Signaling

Results indicate that oligonol exerts antidiabetic activities, which may be mediated via antioxidative, stress-related, anti-inflammatory signaling.

Effect of oligonol, a lychee‐derived polyphenol, on skeletal muscle in ovariectomized rats by regulating body composition, protein turnover, and mitochondrial quality signaling

It is indicated that oligonol treatment had beneficial effects on the skeletal muscle in an estrogen‐deficiency rat model and enhanced mitochondrial biogenesis and dynamics.

Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Oligonol-mediated downregulation of Atrogin-1 and MuRF1 gene expression alleviates muscle loss and improves the impaired myotubes formation, indicating that oligonol supplementation may be useful for the attenuation of myotube loss.

Preventive effect of oligonol on nitric oxide and reactive oxygen species production through regulation of nuclear factor kappa B signaling pathway in RAW 264.7 macrophage cells against sodium nitroprusside

Oligonol attenuated SNP-induced oxidative stress and inflammatory responses via regulation of the NF-κB signalling pathway and is proposed that oligonol may contribute in the prevention and treatment of inflammation-related disorders.

Low-Molecular-Weight Oligonol, a Polyphenol Derived from Lychee Fruit, Attenuates Experimental Reflux Esophagitis and HCl/Ethanol-Induced Gastric Ulcer.

Oligonol had a protective effect against oxidative stress by regulating antioxidant enzyme (superoxide dismutase, catalase, and GPx-1/2) activities in GU mice and has potential as a preventive and therapeutic agent for gastroesophageal inflammatory diseases.
...

39 References

Antioxidative Effects of a New Lychee Fruit-Derived Polyphenol Mixture, Oligonol, Converted into a Low-Molecular Form in Adipocytes

It is suggested that Oligonol has antioxidative effects and that it attenuates HFD-induced dysregulated expression of genes for adipokines in adipocytes.

Oligonol, a new lychee fruit‐derived low‐molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway

It is indicated that Oligonol enhances lipolysis in primary adipocytes, independent of cAMP production, but its effect is dependent on activation of the ERK1/2 pathway, leading to down‐regulation of perilipin protein expression.

Effects of proanthocyanidin preparations on hyperlipidemia and other biomarkers in mouse model of type 2 diabetes.

It is suggested that proanthocyanidin administration, especially the oligomeric form, may improve oxidative stress via the regulation of hyperlipidemia than hyperglycemia in type 2 diabetes.

Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts.

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation.

Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite.

The results provide the first evidence that ONOO(-) can induce protein modification by oxidative cleavage of the Amadori product and also by generation of reactive alpha-oxoaldehydes from glucose.

Role of the receptor for advanced glycation end products in hepatic fibrosis.

Despite upregulation of RAGE in activated HSC, RAGE stimulation by AGE does not alter their fibrogenic activation, and therefore RAGE does not contribute directly to hepatic fibrogenesis.

Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation.

It can be suggested that inhibition of photocarcinogenesis by GSP treatment may be associated with the reduction in UVB-induced oxidative damage and tissue fat content.

Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.

Oligonol Inhibits UVB‐induced COX‐2 Expression in HR‐1 Hairless Mouse Skin—AP‐1 and C/EBP as Potential Upstream Targets †

Oligonol showed antioxidative and anti‐inflammatory effects in UVB‐irradiated mouse skin by inhibiting COX‐2 expression via blockade of the activation of AP‐1 and C/EBP, and upstream kinases including p38 MAP kinase and Akt was attenuated by oligonol.