Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

  title={Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism},
  author={Jeong Sook Noh and Chan Hum Park and Takako Yokozawa},
  journal={British Journal of Nutrition},
  pages={1013 - 1022}
We have identified the effects of oligonol, a low-molecular polyphenol derived from lychee fruit, on oxidative stress and lipid metabolism in a type 2 diabetic model. Oligonol was orally administered at 10 or 20 mg per kg body weight per d for 8 weeks to db/db mice, and its effects were compared with those of the vehicle in db/db and m/m mice. Serum and hepatic biochemical factors, and protein and mRNA expression related to lipid metabolism were measured. In the oligonol-administered group… 

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It is indicated that oligonol treatment had beneficial effects on the skeletal muscle in an estrogen‐deficiency rat model and enhanced mitochondrial biogenesis and dynamics.

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