Treatment with low doses of cabergoline is not associated with increased prevalence of cardiac valve regurgitation in patients with hyperprolactinaemia

@article{Bogazzi2008TreatmentWL,
  title={Treatment with low doses of cabergoline is not associated with increased prevalence of cardiac valve regurgitation in patients with hyperprolactinaemia},
  author={Fausto Bogazzi and Simona Buralli and Luca Manetti and Valentina Raffaelli and Tullio Cigni and Massimo Lombardi and F. Boresi and Stefano Taddei and Alessandra Salvetti and Enio Martino},
  journal={International Journal of Clinical Practice},
  year={2008},
  volume={62}
}
Introduction and aim:  Dopamine agonists have been reported to increase the risk of cardiac valve regurgitation in patients with Parkinson’s disease. However, it is unknown whether these drugs might be harmful for patients with hyperprolactinaemia (HyperPRL). The aim of the study was to evaluate whether HyperPRL patients treated with dopamine agonists had a higher prevalence of cardiac valves regurgitation than that of general population. 
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ORIGINAL ARTICLE: Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia
TLDR
This study examined whether cabergoline treatment of hyperprolactinaemia is associated with a greater prevalence of valvulopathy.
Valvular heart disease and the use of cabergoline for the treatment of prolactinoma
Objective  The use of high doses of the ergot‐derived dopamine agonist cabergoline (> 3 mg/day), especially with cumulative doses > 4000 mg, has been associated with an increase in cardiac valvular…
Cabergoline therapy and the risk of cardiac valve regurgitation in patients with hyperprolactinemia: A metaanalysis from clinical studies
TLDR
It is indicated that echocardiography is recommended in all patients with hyperprolactinemia who are candidate to be treated with or are under cabergoline therapy; monitoring cardiac valves is also recommended although precise follow-up for these patients will be likely provided by future longitudinal studies.
Gender effects on cardiac valvular function in hyperprolactinaemic patients receiving cabergoline: a retrospective study
TLDR
This data indicates that lower doses of cabergoline used to treat prolactinomas withErgot‐derived dopamine agonists are associated with increased risk of valvular dysfunction in Parkinson’s disease.
Cabergoline and cardiac valve disease in prolactinoma patients: additional studies during long-term treatment are required.
TLDR
There is a need for larger, preferably prospective, studies with careful echocardiographic assessment and with longer durations of follow-up than the currently available studies, to raise concern about the safety of the use of cabergoline in the long-term treatment of prolactinomas.
Long-term cabergoline therapy is not associated with valvular heart disease in patients with prolactinomas
TLDR
Low doses of cabergoline seem to be a safe treatment of hyperprolactinemic patients with prolactinomas, however, in patients with prolonged Cabergoline treatment, it is suggested that echocardiographic surveillance may be warranted.
No clinically significant valvular regurgitation in long‐term cabergoline treatment for prolactinoma
An association between treatment for Parkinson's disease with certain dopaminergic drugs and development of cardiac valve impairment has been reported. Recent studies in hyperprolactinaemic patients…
Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease.
TLDR
Cabergoline at doses sufficient to suppress hyperprolactinaemia for a period of 3-4 years is not associated with an increased risk of clinically significant valvular regurgitation.
Risk of Cardiac Valve Regurgitation with Dopamine Agonist use in Parkinson’s Disease and Hyperprolactinaemia
TLDR
Ergot-derived dopamine agonists are associated with an increased risk of CVR in Parkinson’s disease but not in hyperprolactinaemia patients.
Cabergoline therapy for prolactinomas: is valvular heart disease a real safety concern?
TLDR
The clinical significance of the present findings has yet to be confirmed by future larger prospective studies with rigorous echocardiographic protocols and prolonged duration of follow-up, but one study found an increased rate of moderate tricuspid regurgitation.
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References

SHOWING 1-10 OF 31 REFERENCES
Heart valvular disease in patients with Parkinson’s disease treated with high-dose pergolide
TLDR
The authors report the clinical, echocardiographic, and pathologic findings in two patients treated with more than 5 mg of pergolide daily who developed symptomatic severe heart failure due to restrictive valvular disease, suggesting a possible role of high doses of perGolide in inducing restrictive valVular disease.
Valvular heart disease and the use of dopamine agonists for Parkinson's disease.
TLDR
The frequency of clinically important valve regurgitation was significantly increased in Patients taking pergolide or cabergoline, but not in patients taking non-ergot-derived dopamine agonists, as compared with control subjects.
Treatment of Parkinson's disease with pergolide and relation to restrictive valvular heart disease
TLDR
Clinicians should consider changing to a non-ergot drug if this disease is diagnosed, and pergolide treatment was stopped because of restrictive valvular heart disease, in six patients, in two of whom regression of disease was shown.
Dopamine agonists and the risk of cardiac-valve regurgitation.
TLDR
Use of the dopamine agonists pergolide and cabergoline was associated with an increased risk of newly diagnosed cardiac-valve regurgitation.
Severe multivalvular heart disease: A new complication of the ergot derivative dopamine agonists
TLDR
It is proposed that an assessment of cardiac function be performed before and in the course of a long‐term therapy with ergot derivative dopamine agonists, suggesting that the authors may well be facing a novel, yet unrecognized, complication of this class of agents.
Low incidence of restrictive valvulopathy in patients with Parkinson's disease on moderate dose of pergolide
TLDR
The prevalence of restrictive VHD has been lower than expected in Parkinson's disease patients with PD, probably in relation to moderate daily doses of pergolide, and a possible reason for such a discrepancy is that the daily doses in patients were inferior to those reported previously.
Fibrotic valvular heart disease subsequent to bromocriptine treatment.
TLDR
A man who developed fibrosis of three heart valves during a 5-year treatment with bromocriptine for Parkinson disease is described, which to the authors' knowledge has never been described with this drug.
Pergolide use in Parkinson disease is associated with cardiac valve regurgitation
TLDR
If pergolide injures heart valves, resulting most commonly in tricuspid regurgitation, it is found that cardiac valves may injure cardiac valves.
Cabergoline-related severe restrictive mitral regurgitation.
TLDR
The patient had Parkinson's disease that had initially been treated with levodopa, to which cabergoline had been added during the preceding four months, and was notable for increased jugular venous pressure, bilateral rales, and edema in both legs.
Drug Insight: cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women
TLDR
Fewer results are available for men than for women, but there is no evidence that men are less responsive to dopamine agonists than are women.
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