Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

@article{Radu2003TreatmentWI,
  title={Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.},
  author={Roxana A Radu and Nathan L. Mata and Steven Nusinowitz and Xinran N Liu and Paul A. Sieving and Gabriel H. Travis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 8},
  pages={4742-7}
}
Recessive Stargardt's macular degeneration is an inherited blinding disease of children caused by mutations in the ABCR gene. The primary pathologic defect in Stargardt's disease is accumulation of toxic lipofuscin pigments such as N-retinylidene-N-retinylethanolamine (A2E) in cells of the retinal pigment epithelium. This accumulation appears to be responsible for the photoreceptor death and severe visual loss in Stargardt's patients. Here, we tested a therapeutic strategy to inhibit lipofuscin… CONTINUE READING
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