Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin.

@article{Leung1991TreatmentWI,
  title={Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin.},
  author={Donald Y. M. Leung and Ciaran Kelly and Mark Boguniewicz and Charalabos Pothoulakis and John Thomas Lamont and Aurea Flores},
  journal={The Journal of pediatrics},
  year={1991},
  volume={118 4 Pt 1},
  pages={
          633-7
        }
}
We tested the hypothesis that children with chronic relapsing colitis induced by Clostridium difficile toxin have defective antibody responses to C. difficile toxins as a cause of their underlying illness. Six such children were tested for serum IgG and IgA antibody to C. difficile toxin A. These six children had lower IgG anti-toxin A levels than 24 healthy children (p = 0.026) and 18 healthy adults (p = 0.0008). Five patients treated with 400 mg intravenously administered gamma-globulin per… CONTINUE READING

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