Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction.

@article{Couce1996TreatmentWG,
  title={Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction.},
  author={Marta E. Couce and Laurie A. Kane and Timothy O'Brien and Jon A Charlesworth and Walter C. Soeller and J Mcneish and D. K. Kreutter and Paul Roche and Peter C Butler},
  journal={Diabetes},
  year={1996},
  volume={45 8},
  pages={1094-101}
}
Islet amyloid derived from islet amyloid polypeptide (IAPP) is a well-recognized feature of type II diabetes. However, the mechanism of islet amyloidogenesis is unknown. In vitro studies suggest that amino acid residues 20-29 in human, but not mouse, IAPP confer amyloidogenicity consistent with the absence of spontaneous islet amyloidosis in mice. Several clinical and in vitro studies suggest that increased synthetic rates of IAPP predispose to IAPP-amyloidosis. In the present study, we sought… CONTINUE READING

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