Treatment with ginkgo biloba extract protects rats against acute pancreatitis-associated lung injury by modulating alveolar macrophage

@article{Xu2014TreatmentWG,
  title={Treatment with ginkgo biloba extract protects rats against acute pancreatitis-associated lung injury by modulating alveolar macrophage},
  author={Xiao-wu Xu and Xiao-min Yang and Yongheng Bai and Yan-Rong Zhao and Gong-Sheng Shi and Jian-Guo Zhang and Y. Zheng},
  journal={Przegla̜d Gastroenterologiczny},
  year={2014},
  volume={9},
  pages={43 - 48}
}
Introduction Acute pancreatitis (AP) protease release induces lung parenchymal destruction via inflammatory mediators. Ginkgo biloba has been reported to have anti-inflammatory effects. Aim To evaluate the effect of ginkgo biloba extract on experimental acute pancreatitis-associated lung injury in the rat and to investigate the underlying mechanisms. Material and methods Acute pancreatitis was induced in rats by injection of 5% sodium taurocholate into the biliary pancreatic duct. Ginkgo biloba… Expand
Are gastric mucosal macrophages responsible for gastric injury in acute pancreatitis?
TLDR
Gastric macrophages contribute to the pathogenesis of gastric injury in SAP and clodronate-containing liposomes have protective effects against AGMI in rats with SAP. Expand
IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro
TLDR
Treatment with IRF5 siRNA can reverse the pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in SAP associated with ALI. Expand
Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats
TLDR
It is indicated that the induction of HO-1 by hemin pre-treatment significantly ameliorated the L-arginine-induced pancreatitis and associated pulmonary complications may be due to its anti-inflammatory and antioxidant properties. Expand
Proteomic analysis of therapeutic effects of Qingyi pellet on rodent severe acute pancreatitis-associated lung injury.
TLDR
The results showed that, in the SAP group, 9 proteins exhibited obvious changes according to the proteomic analysis, while the data of the QYT group showed that adapter molecule Crk and stathmin were up-regulated, but the other 7 proteins were down-regulated. Expand
The Role of Plant‐derived Products in Pancreatitis: Experimental and Clinical Evidence
TLDR
The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis by summarized the possible mechanistic profile of these phytochemicals. Expand
Chronic Pancreatitis Associated Acute Respiratory Failure.
TLDR
The mechanism that is operational in pancreatitis-associated acute respiratory failure and respiratory distress syndrome in patients and current treatment options is summarized. Expand
Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer
TLDR
The role of MIF signaling pathways in inflammation and cancer is discussed and insights into clinical translation of Mif antagonism as a strategy for treating acute pancreatitis and pancreatic cancer are expected. Expand
Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation
TLDR
The results showed that the culture medium from the activated AR42J cells significantly enhanced NFκB activation in the macrophages compared to that without taurolithocholate treatment, and the precipitates obtained from ultracentrifugation of the culture media that were rich in exosomes were markedly more potent in activating macrophage compared with the supernatant fraction lacking exosome. Expand
Ginkgetin aglycone attenuates the apoptosis and inflammation response through nuclear factor‐kB signaling pathway in ischemic‐reperfusion injury
TLDR
The aim of the study was to investigate the characteristics and function of GA in ischemic‐reperfusion injury in acute myocardial infarction. Expand

References

SHOWING 1-10 OF 19 REFERENCES
Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia.
TLDR
Activation of protease-activated receptor-2 with trypsin, which can be released after pancreatitis induction, positively regulates the transcript level of MIF, and increased MIF results in exaggerated pulmonary expression of TLR-4, leading to the development of ALI with a subsequent infectious attack. Expand
Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver.
TLDR
Lung damage induced by experimental AP is associated with alveolar macrophage activation, and the liver mediates the alveolars activation in this experimental model. Expand
A crucial role of nitric oxide in acute lung injury secondary to the acute necrotizing pancreatitis
TLDR
The results suggest that overproduction of NO mediated by iNOS in the lung is required for the acute lung inflammation and damage secondary to ANP. Expand
Protective effects of Curcuma longa against cerulein-induced acute pancreatitis and pancreatitis-associated lung injury.
TLDR
The administration of CL significantly ameliorated the severity of pancreatitis and pancreatitis-associated lung injury, as was shown by the reduction in pancreatic edema, neutrophil infiltration, vacuolization, necrosis, serum amylase, lipase and cytokine levels, and mRNA expression of multiple inflammatory mediators. Expand
Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis
TLDR
Clodronate-containing liposomes have a protective effect against ALI in rats with SAP, and blockade of macrophages may represent a novel therapeutic strategy in SAP. Expand
Effect of recombinant platelet-activating factor acetylhydrolase on two models of experimental acute pancreatitis.
TLDR
PAF plays an important role in the regulation of pancreatic injury but not pancreatic edema or increased pulmonary microvascular permeability in mild, secretagogue-induced pancreatitis, but can be achieved with rPAF-AH even if treatment is begun after pancreatitis is established. Expand
On the protective mechanisms of nitric oxide in acute pancreatitis
TLDR
It is likely that in pancreatitis NO acts indirectly via microcirculatory changes, including inhibition of leucocyte activation and preservation of capillary perfusion, which is likely to protect against injury caused by pancreatitis in the intact animal. Expand
Ginkgo biloba leaves extract (EGb 761) attenuates lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and NF-κB-dependent matrix metalloproteinase-9 pathway.
TLDR
With EGb 761 pretreatment, both lipopolysaccharide (LPS)-induced protein leakage and neutrophil infiltration, and LPS-induced inflammatory responses including increased myeloperoxidase (MPO) activity, lipid peroxidation, and metalloproteinase (MMP)-9 activity, were inhibited, suggesting that the protection mechanism of EGb 661 is by inhibition of NFκB activation, possibly via the up-regulation of antioxidative enzymes. Expand
Increased nitric oxide excretion in patients with severe acute pancreatitis: evidence of an endotoxin mediated inflammatory response?
TLDR
Total urinary nitrite excretion is increased in patients with severe AP, and may not be simply a reflection of systemic inflammation, but potentially a consequence of endotoxin mediated upregulation of inducible NO synthase activity. Expand
Pathophysiology of Acute Pancreatitis
TLDR
Several animal models of acute pancreatitis have been developed mostly in rodents, although these models fail to reproduce the human disease. Expand
...
1
2
...