Treatment with delta opioid peptide enhances in vitro and in vivo survival of rat dopaminergic neurons.

@article{Borlongan2000TreatmentWD,
  title={Treatment with delta opioid peptide enhances in vitro and in vivo survival of rat dopaminergic neurons.},
  author={Cesario V. Borlongan and T P Su and Yun Wang},
  journal={Neuroreport},
  year={2000},
  volume={11 5},
  pages={923-6}
}
A major problem in neural transplantation therapy is poor survival of grafted cells, which may be due to low cell viability prior to transplantation or scarce trophic factors available to the cells following transplantation. Recently, the delta enkephalin analogue [D-Ala(2),D-Leu(5)]-enkephalin (DADLE) has been demonstrated to protect against, as well as to reverse methamphetamine-induced loss of dopamine transporters. Here, we show that pretreatment with DADLE (0.0025, 0.005, 0.01 g/ml) dose… CONTINUE READING

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