Treatment with cortisone plus heparin or hexuronyl hexoaminoglycan sulfates of murine tumors and their lung deposits

Abstract

Heparin, cortisone, and combination of these two drugs were used for treatment of solitary tumors and artificial lung metastases of the fibrosarcoma NFSA and the mammary carcinoma MCA-K in C3Hf/Kam mice. Heparin reduced the number of artificial metastases of both tumors, but it did not affect the s.c. growth of these tumors. Conversely, cortisone reduced both the number of artificial metastases and the growth rate of s.c. tumors. The effect of cortisone was not further influenced by heparin. Cortisone showed a tendency for causing enhancement of spontaneous metastases. In addition, two heparin analogs, hexuronyl hexaminoglycan sulfates were studied against MCA-K solitary tumors and their spontaneous metastases. They were ineffective when given alone, and they did not influence the effect of cortisone on the s.c. tumor growth. However, they slightly reduced the cortisone-induced enhancement of spontaneous metastases.

DOI: 10.1007/BF01585080

4 Figures and Tables

Statistics

0100200300'92'95'98'01'04'07'10'13'16
Citations per Year

328 Citations

Semantic Scholar estimates that this publication has 328 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Milas1985TreatmentWC, title={Treatment with cortisone plus heparin or hexuronyl hexoaminoglycan sulfates of murine tumors and their lung deposits}, author={Luka Milas and Nancy R. Hunter and Ivan Basic}, journal={Clinical & Experimental Metastasis}, year={1985}, volume={3}, pages={247-255} }