Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study

@article{Mller2003TreatmentWB,
  title={Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study},
  author={Jens Christian M{\"o}ller and Thomas Schaible and C. Robert Roll and Jessica Schiffmann and Lutz Bindl and Lothar Schrod and Irwin K H Reiss and Martina Kohl and Subha Demirakca and Roland Hentschel and Thomas Paul and Anne Vierzig and Peter A Groneck and Heide von Seefeld and Helmut Schumacher and Ludwig Gortner},
  journal={Intensive Care Medicine},
  year={2003},
  volume={29},
  pages={437-446}
}
Objective. To determine whether bovine surfactant given in cases of severe pediatric acute respiratory distress syndrome (ARDS) improves oxygenation. Design. Single-center study with 19 patients, followed by a multicenter randomized comparison of surfactant with a standardized treatment algorithm. Primary endpoint PaO2/FIO2 at 48 h, secondary endpoints: PaO2/FIO2 at 2, 4, 12, and 24 h, survival, survival without rescue, days on ventilator, subgroups analyzed by analysis of variance to identify… CONTINUE READING

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