Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model.

Abstract

Bazedoxifene (BZA), a selective estrogen receptor modulator (SERM), inhibits the action of estrogens on endometrial proliferation. Here, we evaluate the effect of a tissue-selective estrogen complex (TSEC) containing BZA and conjugated estrogens (CE) on ectopic endometrial lesions in a mouse model of endometriosis. Experimental endometriosis was created in… (More)
DOI: 10.1095/biolreprod.113.114165

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