Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

@article{Kieran2004TreatmentWA,
  title={Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice},
  author={Dairin Kieran and Bernadett Kalm{\'a}r and James R. T. Dick and Joanna Riddoch-Contreras and Geoffrey Burnstock and Linda Greensmith},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={402-405}
}
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motoneurons of the spinal cord and motor cortex die, resulting in progressive paralysis. This condition has no cure and results in eventual death, usually within 1–5 years of diagnosis. Although the specific etiology of ALS is unknown, 20% of familial cases of the disease carry mutations in the gene encoding Cu/Zn superoxide dismutase-1 (SOD1). Transgenic mice overexpressing human mutant SOD1 have a phenotype… CONTINUE READING
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Amyotrophic lateral sclerosis : a proposed mechanism

  • B. Kalmar
  • Proc . Natl . Acad . Sci . USA
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