Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies.

@article{Fredrikson2008TreatmentWA,
  title={Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies.},
  author={Gunilla Nordin Fredrikson and Harry Bj{\"o}rkbacka and I. S{\"o}derberg and Irena Ljungcrantz and J. W. Nilsson},
  journal={Journal of internal medicine},
  year={2008},
  volume={264 6},
  pages={563-70}
}
OBJECTIVES Autoantibodies to apolipoprotein (apo) B-100 peptides are present in human plasma and have been shown to be associated with decreased cardiovascular risk. The present study aimed to determine if apo B-100 peptide vaccines are atheroprotective in mice expressing human apo B-100 and if the effectiveness of the vaccines is influenced by the level of pre-existing peptide-specific autoantibodies. DESIGN LDL receptor(-/-)/human apo B-100 transgenic mice were immunized with native human… CONTINUE READING

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