Treatment with anti-CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34 progenitor cells in an allergic mouse model.

@article{Ben2008TreatmentWA,
  title={Treatment with anti-CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34 progenitor cells in an allergic mouse model.},
  author={Su-qin Ben and X Li and Fang Xu and Wu-lin Xu and Wenhui Li and Zu-qun Wu and H Huang and H Z Shi and H-h Shen},
  journal={Allergy},
  year={2008},
  volume={63 9},
  pages={1164-76}
}
BACKGROUND The migration and in situ differentiation of CD34(+) progenitors contribute to inflammatory eosinophilia in asthma and corticosteroids have been widely used in asthma. However, little is know about whether and how corticosteroids modulate the migration and differentiation of CD34(+) progenitors. This study was aimed to investigate the impact of anti-CC chemokine receptor 3 (CCR3) or dexamethasone on inflammatory eosinophilia in asthma and possible mechanism(s) underlying the action… CONTINUE READING
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