Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion

@inproceedings{Shultz2012TreatmentWA,
  title={Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion},
  author={Sandy R. Shultz and Feng Bao and Lynne C. Weaver and Donald Peter Cain and Arthur A. Brown},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
Concussions account for the majority of traumatic brain injuries (TBI) and can result in cumulative damage, neurodegeneration, and chronic neurological abnormalities. The underlying mechanisms of these detrimental effects remain poorly understood and there are presently no specific treatments for concussions. Neuroinflammation is a major contributor to secondary damage following more severe TBI, and recent findings from our laboratory suggest it may be involved in the cumulative properties of… CONTINUE READING