Treatment with an Anabolic-Androgenic Steroid Affects Anxiety-Related Behavior and Alters the Sensitivity of Cortical GABAA Receptors in the Rat

@article{Bitrn1993TreatmentWA,
  title={Treatment with an Anabolic-Androgenic Steroid Affects Anxiety-Related Behavior and Alters the Sensitivity of Cortical GABAA Receptors in the Rat},
  author={Daniel Bitr{\'a}n and Carol K. Kellogg and Robert J. Hilvers},
  journal={Hormones and Behavior},
  year={1993},
  volume={27},
  pages={568-583}
}
The putative psychotropic effect of the anabolic-androgenic steroid, testosterone propionate (TP), was determined in intact adult male rats after 1 or 2 weeks of continued exposure via subcutaneously implanted capsules. Behavior was assessed in a novel open-field arena and in the elevated plus-maze. In addition, gamma-aminobutyric acid (GABA)-stimulated 36chloride (Cl-) influx was determined in cerebral cortical synaptoneurosomes as a function of TP exposure. The weight of the prostate gland… 

The Anabolic Androgenic Steroid Testosterone Propionate Decreases Recognition Memory in Adult Male Rats

Acute or chronic treatments with TP were not effective in promoting changes in spatial working memory and chronic treatment with TP induced significantly increases in biochemistry marker the enzyme glutamate pyruvate transaminase and a reduction in testicular weight as compared with control.

Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors.

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Modulation of affect after chronic exposure to the anabolic steroid 17alpha-methyltestosterone in adult mice.

Results show that systemic exposure to a single AAS modified social behaviors, whereas minimal effects on anxiety-related behaviors were observed according to sex.

Lack of Effects of Anabolic-Androgenic Steroids on Locomotor Activity in Intact Male Mice

It seems that in intact males the steroids' influence on spontaneous locomotor activity may be more subtle than expected, depending on duration of treatment and specific situations (spontaneous or forced activity) as well as the interaction with endogenous androgen levels.

Anxiolytic-like Effect of Testosterone in Male Rats: GABAC Receptors Are Not Involved

The results of the present study showed that administration of testosterone induces anxiolytic-like behaviors in the rats and GABAC receptors possibly are not involved in the anxIOlytic effect of testosterone.

Testosterone promotes anxiolytic-like behavior in gonadectomized male rats via blockade of the 5-HT1A receptors.

The organizational role of testicular hormones and the androgen receptor in anxiety-related behaviors and sensorimotor gating in rats.

A role of T before adulthood is indicated in the organization of anxiety-related behaviors, activity, the hypothalamic-pituitary-adrenal axis, and sensorimotor gating in rats, all of which appears to be AR independent.
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