Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose.

@article{Kahn1990TreatmentWA,
  title={Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose.},
  author={Steven E Kahn and L J Klaff and Michael J. Schwartz and James W. Beard and Richard N Bergman and Gerald J. Taborsky and Daniel Porte},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1990},
  volume={71 4},
  pages={994-1002}
}
To determine the specific alteration in B-cell function caused by a somatostatin analog in man and to determine the effect of the induced insulin deficiency on insulin action, we administered octreotide (SMS 201-995; 50 micrograms twice daily) to nine healthy male subjects, aged 24-35 yr. B-Cell function was assessed by measuring the acute insulin response (AIR) to glucose (AIRglucose) at fasting glucose and to arginine (AIRarg) at glucose concentrations of fasting, approximately 14 and more… CONTINUE READING

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