Treatment with a novel agent combining docosahexaenoate and metformin increases protectin DX and IL-6 production in skeletal muscle and reduces insulin resistance in obese diabetic db/db mice.


AIMS To compare the therapeutic potential of TP-113, a unique molecular entity linking DHA with metformin, for alleviating insulin resistance in obese diabetic mice through the PDX/IL-6 pathway. MATERIAL AND METHODS We utilized the generically obese diabetic db/db mouse model for all experiments. Initial studies investigated both a dose and time course… (More)
DOI: 10.1111/dom.12818


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