Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos.

@article{Akagi2011TreatmentWA,
  title={Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos.},
  author={Satoshi Akagi and Kazutsugu Matsukawa and Eiji Mizutani and Kazuhiro Fukunari and Masahiro Kaneda and Shinya Watanabe and Seiya Takahashi},
  journal={The Journal of reproduction and development},
  year={2011},
  volume={57 1},
  pages={120-6}
}
We examined the effects of treatment with histone deacetylase inhibitors (HDACi), trichostatin A (TSA) and scriptaid (SCR), on the blastocyst formation rate in bovine somatic cell nuclear transferred (SCNT) embryos derived from fibroblast cells. Three fibroblast cell lines (L1, L2 and L3) were used as somatic cell donors to produce SCNT embryos (L1, L2 and L3 embryos, respectively). In Experiment 1, we compared the in vitro developmental competence of L1 embryos treated with various… CONTINUE READING

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