Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss

@inproceedings{Iepsen2015TreatmentWA,
  title={Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss},
  author={Eva Pers Winning Iepsen and J. D. Lundgren and Carsten Dirksen and J K S Jensen and Oluf Pedersen and Thomas v. O. Hansen and Sten Madsbad and J J Holst and Signe S\orensen Torekov},
  booktitle={International Journal of Obesity},
  year={2015}
}
Background:Recent studies indicate that glucagon-like peptide (GLP)-1 inhibits appetite in part through regulation of soluble leptin receptors. Thus, during weight loss maintenance, GLP-1 receptor agonist (GLP-1RA) administration may inhibit weight loss-induced increases in soluble leptin receptors thereby preserving free leptin levels and preventing weight regain.Methods:In a randomized controlled trial, 52 healthy obese individuals were, after a diet-induced 12% body weight loss, randomized… CONTINUE READING