Treatment with Tertiary Oximes Prevents Seizures and Improves Survival Following Sarin Intoxication

@article{Shih2009TreatmentWT,
  title={Treatment with Tertiary Oximes Prevents Seizures and Improves Survival Following Sarin Intoxication},
  author={T Shih and Jacob W. Skovira and John C. O’Donnell and John H. McDonough},
  journal={Journal of Molecular Neuroscience},
  year={2009},
  volume={40},
  pages={63-69}
}
The capability of the tertiary oximes, monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), to reactivate acetylcholinesterase (AChE) inhibited by sarin (GB) in the blood, brain, and peripheral tissues of guinea pigs was compared with that of the quaternary oximes 2-PAM, HLö7, and MMB-4. Animals were injected subcutaneously (s.c.) with 1.0 × LD50 of GB and treated intramuscularly (i.m.) 5 min later with one of these oximes. Sixty minutes after GB exposure, tissues were collected for AChE… CONTINUE READING
12 Citations
22 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Anticholinesterase agents

  • P. Taylor
  • Goodman and Gilman’s the pharmacological basis of…
  • 2001
Highly Influential
6 Excerpts

Effects of choline on somaninduced analgesia and toxicity

  • Shih, T.-M, J. A. Romano
  • Neurotoxicology and Teratology,
  • 1988
Highly Influential
1 Excerpt

Review of nerve agent inhibitors and reactivators of acetylcholinesterase

  • D. H. Moore, C. B. Clifford, I. T. Crawford, G. M. Cole, J. M. Baggett
  • 1995
1 Excerpt

Similar Papers

Loading similar papers…