Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease.

@article{Bennekou2001TreatmentWN,
  title={Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease.},
  author={Poul Bennekou and Lucia De Franceschi and O. Storgaard Pedersen and Lingjun Lian and Tomoaki Asakura and Greg Evans and Carlo Brugnara and Palle Christophersen},
  journal={Blood},
  year={2001},
  volume={97 5},
  pages={1451-7}
}
The dehydration of sickle red blood cells (RBCs) through the Ca-activated K channel depends on the parallel movement of Cl ions. To study whether Cl-conductance block might prevent dehydration of sickle RBCs, a novel Cl-conductance inhibitor (NS3623) was characterized in vitro using RBCs from healthy donors and sickle cell patients and in vivo using normal mice and a transgenic mouse model of sickle cell disease (SAD mice). In vitro, NS3623 reversibly blocked human RBC Cl-conductance (g(Cl… CONTINUE READING

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