Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation

@article{Montes2016TreatmentWA,
  title={Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation},
  author={G. C. Montes and Nathalia Hammes and M. D. da Rocha and T. Montagnoli and Carlos A M Fraga and E. Barreiro and R. T. Sudo and G. Zapata-sudo},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2016},
  volume={358},
  pages={315 - 323}
}
Rheumatoid arthritis is an inflammatory autoimmune condition, and tumor necrosis factor-α (TNF-α) plays an important role in its pathophysiology. In vitro, (E)-N′-(3,4-dimethoxybenzylidene)-N-methylbenzohydrazide (LASSBio-1359) has exhibited anti-TNF-α properties, and in vivo these effects are mediated via activation of adenosine receptor. This work investigates the antinociceptive action of LASSBio-1359 in murine models of acute and chronic inflammatory pain. Male mice received an… Expand
Targeting Adenosine Receptors: A Potential Pharmacological Avenue for Acute and Chronic Pain
Adenosine Signaling in Autoimmune Disorders
Pro-inflammatory Effect of Downregulated CD73 Expression in EAE Astrocytes
Tackling Chronic Pain and Inflammation through the Purinergic System.
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