Treatment with 5-Fluorouracil/Folinic Acid, Oxaliplatin, and Irinotecan Enables Surgical Resection of Metastases in Patients With Initially Unresectable Metastatic Colorectal Cancer

@article{Masi2006TreatmentW5,
  title={Treatment with 5-Fluorouracil/Folinic Acid, Oxaliplatin, and Irinotecan Enables Surgical Resection of Metastases in Patients With Initially Unresectable Metastatic Colorectal Cancer},
  author={Gianluca Masi and Samanta Cupini and Lorenzo Marcucci and Elisa Cerri and Fotios Loupakis and Giacomo Allegrini and Isa Maura Brunetti and Elisabetta Pfanner and M. Viti and Orlando Goletti and Franco Filipponi and Alfredo Falcone},
  journal={Annals of Surgical Oncology},
  year={2006},
  volume={13},
  pages={58-65}
}
The prognosis of unresectable metastatic colorectal cancer might be improved if a radical surgical resection of metastases could be performed after a response to chemotherapy. We treated 74 patients with unresectable metastatic colorectal cancer (not selected for a neoadjuvant approach) with irinotecan, oxaliplatin, and 5-fluorouracil/leucovorin (FOLFOXIRI and simplified FOLFOXIRI). Because of the high activity of these regimens (response rate, 72%), a secondary curative operation could be… CONTINUE READING
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