Treatment-seeking inpatient cocaine abusers show hypothalamic dysregulation of both basal prolactin and cortisol secretion.

@article{Contoreggi2003TreatmentseekingIC,
  title={Treatment-seeking inpatient cocaine abusers show hypothalamic dysregulation of both basal prolactin and cortisol secretion.},
  author={Carlo Contoreggi and Ronald I. Herning and Bonnie Koeppl and Pippa M Simpson and Paulo J Negro and Carolyn Fortner-Burton and Judith Hess},
  journal={Neuroendocrinology},
  year={2003},
  volume={78 3},
  pages={154-62}
}
Cocaine causes neuroendocrine aberrations in cocaine abusers with pituitary stress hormone secretion providing a window to the stress system in the brain. Substance abusers and control participants were hormonally profiled for 3 weeks. Abusers showed significant basal elevations in prolactin in week 1 with normalization over the 3 weeks. No differences in prolactin secretion were seen with either thyrotropin-releasing hormone stimulation or L-dopa suppression testing. Basal afternoon cortisol… CONTINUE READING

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