Treatment-related osteoporosis in men with prostate cancer.

@article{Smith2006TreatmentrelatedOI,
  title={Treatment-related osteoporosis in men with prostate cancer.},
  author={Matthew Raymond Smith},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 20 Pt 2},
  pages={6315s-6319s}
}
The intended therapeutic effect of gonadotropin-releasing hormone (GnRH) agonists is hypogonadism, a major cause of acquired osteoporosis in men. Consistent with this observation, GnRH agonists increase bone turnover and decrease bone mineral density, a surrogate for fracture risk. Large claims-based analyses and other retrospective studies provide compelling evidence that GnRH agonists increase risk of clinical fractures. Estrogens play a central role in homeostasis of the normal male skeleton… CONTINUE READING
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Endocrine profiles during administrationof the newnonsteroidal antiandrogen Casodex in prostate cancer

  • J Verhelst, L Denis, P VanVliet
  • Clin Endocrinol ( Oxf )
  • 2004

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