Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter.


This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed from acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the… (More)


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