Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI.

@article{Heindryckx2005TreatmentOF,
  title={Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI.},
  author={Bj{\"o}rn Heindryckx and Josiane Van der Elst and Petra de Sutter and Marc A Dhont},
  journal={Human reproduction},
  year={2005},
  volume={20 8},
  pages={2237-41}
}
BACKGROUND Failed fertilization occurs in 2-3% of ICSI cycles and is mainly due to lack of oocyte activation. Heterologous ICSI of patient's sperm in mouse oocytes allows discrimination between sperm- and oocyte-related aetiologies of activation failure. Assisted oocyte activation (AOA) by Ca-ionophore treatment can initiate fertilization in subsequent therapeutic ICSI. We report on diagnosis and clinical treatment in 17 patients with previously failed fertilization. METHODS Sperm from… CONTINUE READING

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