Treatment of young children with CNS-positive acute lymphoblastic leukemia without cranial radiotherapy.

Abstract

BACKGROUND Due to the long-term sequelae of cranial radiotherapy (CRT), contemporary treatment protocols for children with acute lymphoblastic leukemia (ALL) aim to limit the use of prophylactic CRT. For patients with central nervous system (CNS) involvement with ALL at diagnosis, the use of CRT remains common. Children <5 years of age are a particularly… (More)
DOI: 10.1002/pbc.25620

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