Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study.

@article{Mannucci2002TreatmentOV,
  title={Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study.},
  author={Pier Mannuccio Mannucci and J. Alexander Chediak and W Rick Hanna and John Byrnes and Marlies Ledford and Bruce M. Ewenstein and Anastassios D Retzios and Barbara A Kapelan and Richard S Schwartz and Craig Kessler},
  journal={Blood},
  year={2002},
  volume={99 2},
  pages={450-6}
}
Among patients with von Willebrand disease (VWD) who are unresponsive to desmopressin therapy, replacement with plasma-derived concentrates is the treatment of choice. Because prospective studies are lacking, such treatment has been largely empirical. A multicenter, prospective study has been conducted in 81 patients with VWD (15 patients with type 1, 34 with type 2, and 32 with type 3 disease) to investigate the efficacy of a high-purity factor VIII/von Willebrand factor (FVIII/VWF… CONTINUE READING
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Pharmacokinetic/Pharmacodynamic Data Analysis: Concepts and Ap plications. 2nd ed

  • J Gabrielsson, D. Weiner
  • 1997
Highly Influential
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