Treatment of valproate tremors.

  title={Treatment of valproate tremors.},
  author={B J Karas and Benjamin Wilder and EsterM. Hammond and Anne Bauman},
  volume={33 10},
Chronic valproate therapy induces symptomatic tremor in about 10% of patients. We studied the effects of propranolol, amantadine, diphenhydramine, benztropine, and cyproheptadine on these tremors in 19 patients by using serial accelerometric recordings. Propranolol was clearly the most therapeutic. Amantadine was moderately effective, but cyproheptadine, diphenhydramine, and benztropine gave little or no relief.