Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies.

@article{Malek2010TreatmentOT,
  title={Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies.},
  author={Rana Malek and Angeline Y Chong and Beatrice C. Lupsa and Andreea O Lungu and E Cochran and Maria A. Soos and Robert K Semple and James E. Balow and Phillip Gorden},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 8},
  pages={
          3641-7
        }
}
BACKGROUND Type B insulin resistance belongs to a class of diseases caused by an autoantibody to a cell surface receptor. Blockade of insulin action results in hyperglycemia, hypercatabolism, severe acanthosis nigricans, and hyperandrogenism in women. This rare autoimmune disorder has been treated with various forms of immunosuppression with mixed success. METHODS We describe 14 patients with type B insulin resistance referred to the National Institutes of Health, adding to an existing cohort… CONTINUE READING

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