Treatment of toxic epidermal necrolysis with the combination of infliximab and high-dose intravenous immunoglobulin.

@article{Gaitanis2012TreatmentOT,
  title={Treatment of toxic epidermal necrolysis with the combination of infliximab and high-dose intravenous immunoglobulin.},
  author={Georgios Gaitanis and Panagiota P. Spyridonos and Konstantinos Patmanidis and Vasilios Koulouras and George Nakos and Margaret Tzaphlidou and Ioannis D. Bassukas},
  journal={Dermatology},
  year={2012},
  volume={224 2},
  pages={134-9}
}
BACKGROUND Therapeutic evidence for toxic epidermal necrolysis (TEN) is indicative for high-dose intravenous immunoglobulin yet inconclusive for corticosteroids. OBJECTIVE To describe the combination of corticosteroids, infliximab and a high-dose intravenous immunoglobulin course for TEN. PATIENTS AND METHODS In three patients (SCORTEN survival probabilities: 41.7%, 64.2%, 41.7%) disease control was evaluated by (a) employing quantitative image analysis to measure progression of skin… CONTINUE READING

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