Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy.

@article{Leone2006TreatmentOT,
  title={Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy.},
  author={M A Leone and Alessandra Solari and Ettore Beghi},
  journal={Neurology},
  year={2006},
  volume={67 12},
  pages={2227-9}
}
We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of… CONTINUE READING

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