Treatment of the budding yeast Saccharomyces cerevisiae with the lipid peroxidation product 4-HNE provokes a temporary cell cycle arrest in G1 phase.

@article{Wonisch1998TreatmentOT,
  title={Treatment of the budding yeast Saccharomyces cerevisiae with the lipid peroxidation product 4-HNE provokes a temporary cell cycle arrest in G1 phase.},
  author={Willibald Wonisch and Sepp D. Kohlwein and J Schaur and Franz Tatzber and Helmut Guttenberger and Neven Zarkovic and Rosita A. Winkler and Harald Esterbauer},
  journal={Free radical biology & medicine},
  year={1998},
  volume={25 6},
  pages={682-7}
}
The effects of 4-hydroxy-2-nonenal (HNE) on the cell division cycle were investigated in the yeast Saccharomyces cerevisiae. A short treatment with HNE at a concentration in the range of the IC50 value in S. cerevisiae SP-4 cells induced a significant increase in the proportion of G0/G1 cells at the expense of S-phase cells. A similar delay in cell cycle progression upon treatment with HNE has recently been shown for HL-60 neoplastic cells. Long-term exposure in a synchronized yeast culture… CONTINUE READING