Treatment of systemic sporotrichosis with ketoconazole.

  title={Treatment of systemic sporotrichosis with ketoconazole.},
  author={D L Calhoun and Hetty Waskin and Madeleine P. White and Judy Bonner and J H Mulholland and L W Rumans and David A Stevens and John N. Galgiani},
  journal={Reviews of infectious diseases},
  volume={13 1},
Infections of deep soft tissues with the dimorphic fungus Sporothrix schenckii are uncommon in humans, and therapy has often required toxic drugs. We report our experience in treating 11 patients who had deep-seated sporotrichosis with ketoconazole, a well-tolerated, orally absorbed antifungal agent. Eight infections involved one or more joints, and three involved thoracic, cervical, and widespread cutaneous sites, respectively. For eight patients all evidence of infection resolved during… CONTINUE READING

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