Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine.


We used three to six courses of 2-chlorodeoxyadenosine (2-CdA) (2-h infusion at 0.14 mg/kg per day x 5 days) given over a period of 3-36 months to treat four patients with aggressive systemic mast cell disease (SMCD) that was resistant to interferon-alpha (IFN-alpha). Treatment with 2-CdA resulted in a major response in two patients and a good partial… (More)


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@article{Pardanani2004TreatmentOS, title={Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine.}, author={Animesh Dev Pardanani and A. Victor Hoffbrand and J. H. Butterfield and Ayale Tefferi}, journal={Leukemia research}, year={2004}, volume={28 2}, pages={127-31} }