Treatment of splenic marginal zone lymphoma: splenectomy versus rituximab.

  title={Treatment of splenic marginal zone lymphoma: splenectomy versus rituximab.},
  author={Michael Bennett and Geraldine P Schechter},
  journal={Seminars in hematology},
  volume={47 2},
Splenic marginal zone lymphoma (SMZL) is an uncommon indolent B-cell lymphoma causing marked splenic enlargement with CD20-rich lymphoma cells infiltrating blood and bone marrow. In the pre-rituximab era, the treatment of choice for patients with symptomatic splenomegaly or threatening cytopenia was splenectomy, since chemotherapy had limited efficacy. Responses to splenectomy occurred in approximately 90% of patients. However, SMZL patients are often elderly and poor surgical risks. Since… CONTINUE READING


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