Treatment of severe pemphigus with protein A immunoadsorption, rituximab and intravenous immunoglobulins.

@article{Shimanovich2008TreatmentOS,
  title={Treatment of severe pemphigus with protein A immunoadsorption, rituximab and intravenous immunoglobulins.},
  author={Iakov Shimanovich and Martin Nitschke and Christian Rose and J{\"u}rgen Grabbe and Detlev Zillikens},
  journal={The British journal of dermatology},
  year={2008},
  volume={158 2},
  pages={382-8}
}
BACKGROUND Pemphigus is a life-threatening autoimmune blistering disease usually treated with high-dose corticosteroids and other immunosuppressants. However, this regimen may prove inadequate in severe cases and cause dangerous side-effects. While protein A immunoadsorption (PAIA) induces a rapid remission in severe pemphigus, the disease usually recurs once the treatment is stopped. In contrast, anti-CD20 antibody rituximab has a delayed onset of action but may lead to a long-term remission… CONTINUE READING

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