Treatment of secondary depression in schizophrenia. A double-blind, placebo-controlled trial of amitriptyline added to perphenazine.

@article{Prusoff1979TreatmentOS,
  title={Treatment of secondary depression in schizophrenia. A double-blind, placebo-controlled trial of amitriptyline added to perphenazine.},
  author={Brigitte A Prusoff and David H Williams and Myrna M. Weissman and Boris M. Astrachan},
  journal={Archives of general psychiatry},
  year={1979},
  volume={36 5},
  pages={569-75}
}
The combination of antidepressants and neuroleptics has been widely recommended and commonly used clinically for the schizophrenic patient who becomes depressed. However, the value of the combination for these patients has not been clearly demonstrated. This report presents results of a double-blind, randomized, placebo-controlled clinical trial designed to evaluate the combination of perphenazine and amitriptyline hydrochloride with that of perphenazine alone in the treatment of 35 ambulatory… CONTINUE READING