Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors.

@article{elKouni1987TreatmentOS,
  title={Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors.},
  author={Mahmoud H. el Kouni and Norma J. Messier and Sungman Cha},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 22},
  pages={
          3815-21
        }
}
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42 Citations
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7
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Results Citations
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42 Citations

Efficacy of the tubercidin antileishmania action associated with an inhibitor of the nucleoside transport
TLDR
It is demonstrated that TUB–NBMPR combined treatment can be effective against leishmania cells protecting mammalian cells from TUB toxicity.
Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii
TLDR
It appears that the unique characteristics of purine metabolism in T. gondii render certain 6-substituted 9-β-d-ribofuranosylpurines promising antitoxoplasmic drugs.
In vivo effectiveness of several nucleoside transport inhibitors in mice and hamsters
TLDR
The results demonstrate the potential of the mioflazine derivative R75231 to be useful in vivo, possibly even after p. o. administration, for host protection against the actions of cytotoxic nucleosides used in experimental antiparasitic therapy or other studies requiring suppression of nucleoside transport.
Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis
TLDR
Host toxicity of the dose regimen of tubercidin plus nitrobenzylthioinosine 5'-monophosphate (NBMPR-P) used in combination therapy of schistosomiasis was examined in vivo in mice and in vitro with human bone marrow progenitor cells, showing no evidence for injury to the liver, kidney, spleen, pancreas, mesentery, or peritoneal mesothelium.
6-Benzylthioinosine analogues: promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es).
Efficacy of combination therapy with tubercidin and nitrobenzylthioinosine 5'-monophosphate against chronic and advanced stages of schistosomiasis
Protection against fludarabine neurotoxicity in leukemic mice by the nucleoside transport inhibitor nitrobenzylthioinosine
TLDR
It was shown that in mice implanted with leukemia L1210, fatal neurotoxicity, which initially manifested as hind-limb paralysis, was a consequence of high-dose-F-ara-AMP treatment, but the incidence of neurotoxicity was reduced by the coadministration of NBMPR-P, the 5′-phosphate of nitrobenzylthioinosine, a potent inhibitor of thees equilibrative nucleoside transport (NT) system.
Immunization with Purine Salvation Pathway Recombinant Enzymes Induces the Production Of Anti- Schistosoma Mansoni Immunoglobulines
TLDR
Assessment of the production of total IgG, IgE and IgG2a in the plasma after immunization with the PNP, HGPRT and ADK enzymes, using the S. mansoni cercariae - infected murine model showed that the immunization in Balb/c mice with the enzymes induced production of the immunoglobulines at the 48 and 85 th days.
Uptake of Nitrobenzylthioinosine and Purine β-l-Nucleosides by Intracellular Toxoplasma gondii
TLDR
Infection with T. gondii confers the properties of the parasite's purine nucleoside transport on the parasitized host cells and enables the infected cells to transport purines that were not transported by uninfected cells, which may aid in the identification of new promising antitoxoplasmic drugs.
Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues.
TLDR
The results reveal that the Schistosoma mansoni AK can be sterically occluded in the absence of ATP, and contribute to the body of knowledge concerning the enzymes of the purine salvage pathway in this important human parasite.
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References

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TLDR
In the presence of nitrobenzylthioinosine (NBMPR), Roswell Park Memorial Institute 6410 cells proliferating in culture were protected from otherwise inhibitory concentrations of 9-beta-D-ribofuranosylpurine (nebularine); cellular uptake of nebularine was greatly reduced under these circumstances.
Combination therapy of Schistosoma japonicum by tubercidin and nitrobenzylthioinosine 5'-monophosphate.
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TLDR
The coadministration of tubercidin and ethidium to mice infected with Trypanosoma gambiense gave a better parasite clearance than either of the single drugs and the inclusion of nitrobenzylthioinosinate in the therapy significantly alleviated the toxicity of the drug combination.
NUCLEOSIDE ANALOGS AS ANTIPARASITIC AGENTS *
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  • Biology
    Annals of the New York Academy of Sciences
  • 1975
TLDR
Evidence is now at hand to indicate that there are peculiarities in the biochemistry and physiology of diverse kinds of parasites that theoretically are exploitable for chemotherapy by nucleoside analogs.
Growth inhibition of axenic Entamoeba histolytica by tubercidin and ara-A.
TLDR
Tubercidin and ara-A, analogs of adenosine, were the most potent of the tested growth inhibitors with amebistatic concentrations of about 0.6 and 3.0 microM, respectively, and in the present study metronidazole and emetine had 17- and 60-fold higher than tuberCidin.
Inhibition of nucleoside transport in murine lymphoma L5178Y cells and human erythrocytes by the uridine phosphorylase inhibitors 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine.
TLDR
The inhibitory effects on the efflux of preloaded uridine indicate that BAU and BBAU are inhibitors, rather than permeants, of the nucleoside transport system.
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