Treatment of restless legs syndrome with pregabalin: a double-blind, placebo-controlled study.

@article{GarcaBorreguero2010TreatmentOR,
  title={Treatment of restless legs syndrome with pregabalin: a double-blind, placebo-controlled study.},
  author={Diego Garc{\'i}a-Borreguero and Oscar Larrosa and A. Williams and Javier Albares and M. Deseada Gutierrez Pascual and Jos{\'e} Palacios and Cristina Fernandez},
  journal={Neurology},
  year={2010},
  volume={74 23},
  pages={1897-904}
}
OBJECTIVES To assess the therapeutic efficacy, required dose, and tolerability of pregabalin in patients with idiopathic restless legs syndrome (RLS). METHODS This was a double-blind, placebo-controlled trial with polysomnographic control, providing Class II evidence. Ninety-eight patients underwent a 2-week single-blind period with placebo; 58 were randomized to receive pregabalin or placebo for 12 weeks under a flexible-dose schedule. Endpoints were mean change from baseline in the… CONTINUE READING
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