Treatment of resistant intracranial hypertension with hypertonic saline. Report of two cases.

@article{Worthley1988TreatmentOR,
  title={Treatment of resistant intracranial hypertension with hypertonic saline. Report of two cases.},
  author={Lindsay I G Worthley and Dr. D. J. Cooper and Nigel Jones},
  journal={Journal of neurosurgery},
  year={1988},
  volume={68 3},
  pages={478-81}
}
The authors describe two patients with traumatic cerebral edema and intracranial hypertension in whom the continued use of mannitol and furosemide resulted in a progressive lessening of the effect of these agents on the intracranial pressure (ICP) and caused prerenal failure. Intravenous administration of hypertonic saline (50 ml and 20 ml of a 5-mmol/ml saline solution over 10 minutes in Cases 1 and 2, respectively) produced a prolonged reduction in the ICP and improved renal function in both… CONTINUE READING

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